Overview
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide (pentadecapeptide) derived from a protective sequence identified in gastric juice. It is one of the most extensively studied peptides in preclinical tissue-repair research.
Mechanism of action
- Angiogenesis via the VEGFR2–Akt–eNOS pathway: in vitro studies on endothelial cells show increased VEGFR2 expression and its internalisation.
- Modulation of the nitric oxide (NO) pathway and cytoprotective mechanisms.
- Involvement of the Src–Caveolin-1 and FAK–paxillin pathways in cell migration.
Research context
Available data are predominantly preclinical (in vitro and animal models): wound healing, tendons and ligaments, gastrointestinal mucosa, vascular recovery (CAM assays, endothelial tube formation). There is no large-scale human clinical trial; these results are not transferable to humans.
Quality assurance
- Purity ≥ 99 % verified by HPLC
- Certificate of Analysis (COA) available per batch
- Traceability: unique batch number on every vial
Format & handling
Presentation: lyophilised powder, 10 mg / vial · Reconstitution: bacteriostatic water · Storage: refrigerate the lyophilisate; after reconstitution, keep cold and protected from light.
References
- « Therapeutic potential of pro-angiogenic BPC-157 associated with VEGFR2 activation » (preclinical research).
- « Modulatory effects of BPC 157… Src-Caveolin-1-eNOS pathway », Scientific Reports, 2020.
For research use only. Product intended exclusively for scientific and laboratory research. Not intended for human or animal consumption.
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